Participants 200 schools were randomly selected from all state run primary schools within 35 miles of the study centre … DiRECT is an open-label, cluster-randomised, controlled trial done at primary care practices in the UK. VLCD for weight loss and remission of type 2 diabetes? 8 million people in England now have diabetes. To read this article in full you will need to make a payment. 10-year follow-up of intensive glucose control in type 2 diabetes. The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. Objective To assess the effectiveness of a school and family based healthy lifestyle programme (WAVES intervention) compared with usual practice, in preventing childhood obesity. Association of an intensive lifestyle intervention with remission of type 2 diabetes. The Lancet Regional Health – Western Pacific, Advancing women in science, medicine and global health, Semaglutide once weekly as add-on to SGLT-2 inhibitor therapy in type 2 diabetes (SUSTAIN 9): a randomised, placebo-controlled trial, Access any 5 articles from the Lancet Family of journals, National Institute for Health and Care Excellence, Scottish Intercollegiate Guideline Network, https://doi.org/10.1016/S2213-8587(19)30068-3, Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial, https://www.diabetes.org.uk/resources-s3/2017-11/diabetes-key-stats-guidelines-april2014.pdf, https://www.cdc.gov/diabetes/pdfs/data/statistics/national-diabetes-statistics-report.pdf, http://www.who.int/diabetes/global-report/en/, https://www.sign.ac.uk/assets/sign116.pdf, Recommend Lancet journals to your librarian, National Centre for Chronic Disease Prevention and Health Promotion. Reversal of type 2 diabetes after bariatric surgery is determined by the degree of achieved weight loss in both short- and long-duration diabetes. Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased β-cell turnover. Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Students, parents, and educators can use Career Clusters to help focus education plans towards obtaining the necessary knowledge, competencies, and training for success in a particular career pathway. Making the cluster a lot larger while keeping the number of clusters fixed might yield only a very small increase in power and precision, owing to the intracluster correlation. BURLINGTON, N.C. — The Alamance County Health Department has identified COVID-19 clusters at 3 child care centers, according to a statement … Top ten research priorities for type 2 diabetes: results from the Diabetes UK–James Lind Alliance Priority Setting Partnership. The DiRECT programme sustained remissions at 24 months for more than a third of people Cluster randomised trials have diminishing returns in power and precision as cluster size increases. Life expectancy and cause-specific mortality in type 2 diabetes: a population-based cohort study quantifying relationships in ethnic subgroups. Type 2 diabetes: the pathologic basis of reversible beta-cell dysfunction. Ten dead after Covid-19 cluster at care home By Lucinda Cameron, PA Scotland. Current insights into pathophysiology, diagnosis and treatment. © 2017 Elsevier Ltd. All rights reserved. Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. Feasibility and indicative results from a 12-month low-energy liquid diet treatment and maintenance programme for severe obesity. Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery. VLCD for weight loss and remission of type 2 diabetes? Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Long-term progression of retinopathy after initiation of insulin therapy in Type 2 diabetes: an observational study. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Design Cluster randomised controlled trial. We did this open-label, cluster-randomised trial (DiRECT) at 49 primary care practices in Scotland and the Tyneside region of England. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. The Lancet Regional Health – Western Pacific, Advancing women in science, medicine and global health, Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials, Access any 5 articles from the Lancet Family of journals, https://doi.org/10.1016/S0140-6736(17)33102-1, Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial, https://www.gov.uk/government/news/38-million-people-in-england-now-have-diabetes, http://www.who.int/diabetes/global-report/en/, https://doi.org/10.1007/s00125-017-4503-0, http://dx.doi.org/10.1016/S2213-8587(17)30324-8, https://obesityweek.com/abstract/counterweight-plus-an-intensive-non-surgical-option-for-severe-obesity/, Remission of type 2 diabetes: mission not impossible. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Glycaemic effects of intensive caloric restriction and isocaloric refeeding in non-insulin dependent diabetes mellitus. Very low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders. Original Article from The New England Journal of Medicine — A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19 ... Health care worker: 131 (11.7) 130 (10… Weight loss decreases excess pancreatic triacylglycerol specifically in type 2 diabetes. Management of hyperglycaemia in type 2 diabetes, 2018. Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1 year follow up. Life expectancy and cause-specific mortality in type 2 diabetes: a population-based cohort study quantifying relationships in ethnic subgroups. Drugs used to treat Cluster Headaches The following list of medications are in some way related to, or used in the treatment of this condition. Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Reversibility of metabolic and morphological changes associated with chronic exposure of pancreatic islet beta-cells to fatty acids. Large scale population assessment of physical activity using wrist worn accelerometers: the UK Biobank Study. Sustained remission was linked to the extent of sustained weight 0 comment. National diabetes statistics report, 2017: estimates of diabetes and its burden in the United States. Aim To evaluate the effectiveness of a ‘Do not interrupt’ bundled intervention to reduce non-medication-related interruptions to nurses during medication administration. 0001) and in HbA. Ten people have died after contracting Covid-19 following an outbreak at a care home. Review of the key results from the Swedish Obese Subjects (SOS) trial—a prospective controlled intervention study of bariatric surgery. Glycaemic effects of intensive caloric restriction and isocaloric refeeding in non-insulin dependent diabetes mellitus. NHS Fife said 25 residents and 43 staff tested positive for the virus at Mossview Care Home in Lochgelly. loss. The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Effects of a very-low-calorie diet on long-term glycemic control in obese type 2 diabetic subjects. Philadelphia has its pharmaceutical cluster, San Francisco is known for its tech startups, and Boston boasts about its investment capital. Counterweight-Plus: an intensive, non-surgical option for severe obesity. Current insights into pathophysiology, diagnosis and treatment. Association of an intensive lifestyle intervention with remission of type 2 diabetes.